Wednesday 9:30 am - 10:30 am
INSTRUCTOR
Dr. Vladimir Hlady (BPRB 108D, 581-5042, Vladimir.Hlady@utah.edu)
Cell Adhesion is an independent study for intermediate to advanced graduate students that will explore the relationship between tissue, cell, and protein engineering to cell adhesion. The study is designed to give each student an understanding of the fundamentals of cell adhesion, to get them to think about the relationship between the biology of cell adhesion and engineering concerns, and provide access to a body of literature on the subject. As such, all course materials provided by the instructor and turned in by the students will be available on the course website as the semester progresses.
Course Organization / Assignments:
No assignments are due during the first session. Assigned readings will be specified by the instructor one week in advance.
Before each topic session every student has the following assignments:
• Read that topic’s assigned paper
• Re-read the assigned paper
• Write a critical summary of the assigned paper. DO NOT rewrite the abstract – summarize then critique the paper, and submit typed summary (less than one page)
• Obtain, preferably from high impact journal, and critically read at least one additional paper related to the topic of the assigned paper, submit the citation and pdf copy of the additional paper for your choice at least one day in advance to the instructor via email for review,
• Optionally read additional background literature on the topic
• Prepare to turn in the critical summary and a pdf copy of the additional paper to the instructor at the beginning of the relevant session
Additionally, one student per topic session will prepare a 20 minute presentation on the topic and lead the ensuing topic and paper discussions. Students should arrange for all required presentation aids (projectors, markers, laser pointers, etc) on their own. All materials presented are to be turned in to the instructors at the end of the session. Topic session presentation assignments (see below) will be confirmed the first course meeting.
COURSE SCHEDULE and MATERIALS
(Note: Materials will be added as the course progresses - Please check back often.)
Week. Date
1. January 12 Syllabus Presentation, Topic Assignments
2. January 19 Topic 0: Why Cell Adhesion? (VH intro)
3. January 26 Topic 1: ECM and Cytoskeleton (VS report)
(assigned paper, background review, LEC, VS, TH, KJ, CE papers)
4. February 2 Topic 2: Integrins (LEC report) (VH out of town)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
5. February 9 Topic 3: Selectins (CE report)
(assigned paper, background review, LEC, VS, TH, KJ, CE papers)
6. February 16 Topic 4: NCAMs and IgCAMs (TH report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
7. February 23 Topic 5: Cell surface PGs (KJ report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
8. March 2 Topic 6: Others: ADAMs, Cell-Surface Protein Tyrosine Phosphatases, etc.(VS report)
(assigned paper, previously reviewed paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
9. March 9 Topic 7: Cadherins and Junctions (CE report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
10. March 16 Topic 8: Focal Adhesions and Contacts (LEC report)
(assigned paper, papers on RICM spreading and contacts, LEC, VS, TH, KJ, CE papers)
11. March 23 Spring Break
12. March 30 Topic 9: Growth cone, axon guidance and repulsion (TH report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
13. April 6 Topic 10: Mechanotransduction (KJ report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
14. April 13 Topic 11: Cell Adhesion and Cancer (VS report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
15. April 20 Topic 12: Inflammation: leukocyte capture, rolling and adhesion (CE report)
(assigned paper, background review1 and review2, LEC, VS, TH, KJ, CE papers)
Each topic session will be organized as follows:
9:30 – 9:35 Hand in assignments, presentation set-up
9:35 – 9:55 Topic presentation
9:55 – 10:10 Topic discussion
10:10 - 10:30 Paper(s) review
Grading is based on participation and the completion of 2-3 presentations and 15 assignments.