(written in collaboration with C.-H. Ho, P.Dryden and D. W. Britt , Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA).
CONTENT Introduction, Protein adsorption isotherms Protein adsorption kinetics, Protein-surface interactions, Methods used to study protein adsorption Quantitative analysis of the protein adsorption kinetics Computation of the flux of protein molecules to the adsorbent surface Quantification of protein adsorption kinetics based on the transport-limited adsorption from flowing solution Quantification of protein adsorption kinetics based on one point measurement using radiolabeled protein Example: Modeling the kinetics of lipoprotein adsorption Step 1. Finding the desorption rate constant Step 2. Estimates for other fitting parameters Step 3. Interpretation of the parameters obtained by fitting Adsorption cooperativity, Coda, References